Oct. 12, 2007 — When aging hampers memory, some people's brains compensate to stay sharp. Now scientists want to know how those brains make do — in hopes of developing treatments to help everyone else keep up.
This is not Alzheimer's disease, but the wear-and-tear of so-called normal aging. New research is making clear that memory and other brain functions decline to varying degrees even in otherwise healthy people as they age, as anyone who habitually loses car keys probably suspected.
The question is how to gird our brains against time's ravages, a question becoming critical as the population grays. If you're 65 today, odds are you'll live to 83. But improving health care means people in their 50s today may live another 40 years.
"I don't think we've recognized, as scientists or a society, (that) this is the front-and-center public health issue we face as a nation," Dr. Denise Park, director of the University of Illinois' Center for Healthy Minds, told fellow brain specialists assembled by the government last week.
"We need to understand how to defer normal cognitive aging ... the way we've invested in fighting heart disease and cancer."
There are intriguing clues, gleaned from discoveries that some seniors' brains literally work around aging's damage, forging new pathways when old ones disintegrate.
"It's not just fanciful or pie-in-the-sky" to try harnessing that ability, said Dr. Richard Hodes, director of the National Institute on Aging, which organized last week's meeting to seek advice on the most promising research.
High on the list: Simple physical exercise. It seems to do the brain as much good as the body.
Other options aren't as well-studied, but range from brain-training games to medications that may keep brain networks better connected. In fact, an old blood-pressure pill named guanfacine improves memory in old rats and monkeys by doing just that — but it hasn't yet been tested in older people with memory problems.
What's normal aging and what signals impending Alzheimer's? That is a big question for elders worried about periodic memory lapses. Science can't yet tell for sure, but there seem to be distinct differences.
Consider: A healthy brain is a bushy one. Branch-like tentacles extend from the ends of the brain's cells, enabling them to communicate with each other. The more you learn, the more those connections form.
This is not Alzheimer's disease, but the wear-and-tear of so-called normal aging. New research is making clear that memory and other brain functions decline to varying degrees even in otherwise healthy people as they age, as anyone who habitually loses car keys probably suspected.
The question is how to gird our brains against time's ravages, a question becoming critical as the population grays. If you're 65 today, odds are you'll live to 83. But improving health care means people in their 50s today may live another 40 years.
"I don't think we've recognized, as scientists or a society, (that) this is the front-and-center public health issue we face as a nation," Dr. Denise Park, director of the University of Illinois' Center for Healthy Minds, told fellow brain specialists assembled by the government last week.
"We need to understand how to defer normal cognitive aging ... the way we've invested in fighting heart disease and cancer."
There are intriguing clues, gleaned from discoveries that some seniors' brains literally work around aging's damage, forging new pathways when old ones disintegrate.
"It's not just fanciful or pie-in-the-sky" to try harnessing that ability, said Dr. Richard Hodes, director of the National Institute on Aging, which organized last week's meeting to seek advice on the most promising research.
High on the list: Simple physical exercise. It seems to do the brain as much good as the body.
Other options aren't as well-studied, but range from brain-training games to medications that may keep brain networks better connected. In fact, an old blood-pressure pill named guanfacine improves memory in old rats and monkeys by doing just that — but it hasn't yet been tested in older people with memory problems.
What's normal aging and what signals impending Alzheimer's? That is a big question for elders worried about periodic memory lapses. Science can't yet tell for sure, but there seem to be distinct differences.
Consider: A healthy brain is a bushy one. Branch-like tentacles extend from the ends of the brain's cells, enabling them to communicate with each other. The more you learn, the more those connections form.
Discovery News
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